The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior
نویسندگان
چکیده
Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers selfassembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles. 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CCBY license (http://creativecommons.org/licenses/by/4.0/).
منابع مشابه
Amphiphilic Block Copolymer Nano-micelles: Effect of Length Ratio of the Hydrophilic Block
Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...
متن کاملSelf-Assembly of Amphiphilic Block Copolymers in Selective Solvents
For the last decades, amphiphilic block copolymers have been at the focus of extensive scientific interest, due to their unique properties and numerous potential applications. Their technological potential evolves from their ability to self-assemble into a plethora of morphologically diverse nanostructures such as micelles, polymersomes, cylinders and others. In this chapter, we discuss the bas...
متن کاملSupramolecular self-assembly of nonlinear amphiphilic and double hydrophilic block copolymers in aqueous solutions.
Supramolecular self-assembly of block copolymers in aqueous solution has received ever-increasing interest over the past few decades due to diverse biological and technological applications in drug delivery, imaging, sensing and catalysis. In addition to relative block lengths, molecular weights and solution conditions, chain architectures of block copolymers can also dramatically affect their ...
متن کاملA Record Nine Different Phases (Four Cubic, Two Hexagonal, and One Lamellar Lyotropic Liquid Crystalline and Two Micellar Solutions) in a Ternary Isothermal System of an Amphiphilic Block Copolymer and Selective Solvents (Water and Oil)
We report on a ternary isothermal system consisting of a poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) amphiphilic block copolymer, “water”, and “oil” (where “water” and “oil” are selective solvents for the different blocks), which exhibits the richest structural polymorphism ever observed (in equilibrium) inmixtures containing amphiphiles (such as block copolymers, surfactants, or lipid...
متن کاملSelf-Assembly of Block and Graft Copolymers in Organic Solvents: An Overview of Recent Advances
This review is an attempt to update the recent advances in the self-assembly of amphiphilic block and graft copolymers. Their micellization behavior is highlighted for linear AB, ABC triblock terpolymers, and graft structures in non-aqueous selective polar and non-polar solvents, including solvent mixtures and ionic liquids. The micellar characteristics, such as particle size, aggregation numbe...
متن کامل